Spatial Distribution of Biomaterial Microenvironment pH and Its Modulatory Effect on Osteoclasts at the Early Stage of Bone Defect Regeneration

Author:

Liu Wenlong1ORCID,Dan Xiuli2,Lu William W.3,Zhao Xiaoli1ORCID,Ruan Changshun1ORCID,Wang Ting4,Cui Xu1,Zhai Xinyun13,Ma Yufei1,Wang Deping5,Huang Wenhai5,Pan Haobo1ORCID

Affiliation:

1. Research Center for Human Tissue and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

2. School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, 999077 Hong Kong, China

3. Department of Orthopaedics and Traumatology, Faculty of Medicine, The University of Hong Kong, 999077 Hong Kong, China

4. Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma, Department of Orthopaedics, The University of Hong Kong-Shenzhen Hospital, University of Hong Kong, Shenzhen 518053, China

5. Institute of Bioengineering and Information Technology Materials, School of Materials Science and Engineering, Tongji University, Shanghai 200092, China

Funder

National Natural Science Foundation of China

Shenzhen Science and Technology Research Funding

Strategic Priority Research Program A of Chinese Academy of Science

Highlight Research of Frontier Science, Chinese Academy of Sciences

Shenzhen Peacock Program

Youth Innovation Promotion Association CAS

Publisher

American Chemical Society (ACS)

Subject

General Materials Science

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