Nongenomic Actions of Bile Acids. Synthesis and Preliminary Characterization of 23- and 6,23-Alkyl-Substituted Bile Acid Derivatives as Selective Modulators for the G-Protein Coupled Receptor TGR5-Reference-Cited by-同舟云学术

Nongenomic Actions of Bile Acids. Synthesis and Preliminary Characterization of 23- and 6,23-Alkyl-Substituted Bile Acid Derivatives as Selective Modulators for the G-Protein Coupled Receptor TGR5

Published:2007-08-09 Issue:18 Volume:50 Page:4265-4268
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Pellicciari Roberto¹,Sato Hiroyuki¹,Gioiello Antimo¹,Costantino Gabriele¹,Macchiarulo Antonio¹,Sadeghpour Bahman M.¹,Giorgi Gianluca¹,Schoonjans Kristina¹,Auwerx Johan¹

Affiliation:

1. Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Via del Liceo 1, 06123 Perugia, Italy, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, 67404 Illkirch, France, Dipartimento di Chimica, Università degli Studi di Siena, via Aldo Moro, I-53100 Siena, Italy, and Institut Clinique de la Souris (ICS), 67404 Illkirch, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm070633p

Reference28 articles.

1. Endocrine functions of bile acids

2. Identification of a Nuclear Receptor for Bile Acids

3. Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

4. Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

5. Farnesoid X Receptor: From Structure to Potential Clinical Applications

Cited by 97 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A practical chemical synthesis of avicholic acid;Tetrahedron Letters;2024-05

2. Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7- and C23-Substituted cholic acid derivatives;European Journal of Medicinal Chemistry;2023-12

3. Gastrointestinal neoplasia: carcinogenic interaction between bile acids and Helicobacter pylori in the stomach;Journal of Clinical Investigation;2022-05-16

4. Beyond lipids: Novel mechanisms for parenteral nutrition–associated liver disease;Nutrition in Clinical Practice;2022-02-06

5. Gut Dysbiosis and Immune System in Atherosclerotic Cardiovascular Disease (ACVD);Microorganisms;2022-01-05