1. Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7260 USA, Graduate School of Frontier Biosciences, Osaka University and CREST Japan Science and Technology Corporation, 1-3 Yamada-oka, Osaka 565-0871, Japan, and RIKEN, Wako-shi, Saitama 351-0198, Japan