Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR)-Reference-Cited by-同舟云学术

Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR)

Published:2009-01-21 Issue:4 Volume:52 Page:904-907
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Flatt Brenton¹,Martin Richard¹,Wang Tie-Lin¹,Mahaney Paige¹,Murphy Brett¹,Gu Xiao-Hui¹,Foster Paul¹,Li Jiali¹,Pircher Parinaz¹,Petrowski Mary¹,Schulman Ira¹,Westin Stefan¹,Wrobel Jay¹,Yan Grace¹,Bischoff Eric¹,Daige Chris¹,Mohan Raju¹

Affiliation:

1. Departments of Medicinal Chemistry, Structural Biology, Molecular Biology, Lead Discovery, and Pharmacology, Exelixis Inc., 4757 Nexus Centre Drive, San Diego, California 92121, and 169 Harbor Way, South San Francisco, California 94083, and Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8014124

Reference29 articles.

1. Identification of a nuclear receptor that is activated by farnesol metabolites

2. The nuclear receptor superfamily: The second decade

3. A Unified Nomenclature System for the Nuclear Receptor Superfamily

4. FXR, a multipurpose nuclear receptor

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