A Unified and Quantitative Receptor Model for the Microtubule Binding of Paclitaxel and Epothilone

Author:

Wang Minmin1,Xia Xiaoyang1,Kim Yohan1,Hwang David1,Jansen Johanna M.1,Botta Maurizio1,Liotta Dennis C.1,Snyder James P.1

Affiliation:

1. Department of Chemistry,Emory University, Atlanta, Georgia 30322, Chiron Corp., Emeryville, California 94608, and Dip. Farmaco Chimico Tecnologico, University of Siena, 55-53100 Italy

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference49 articles.

1. (a) Jordon, M. A.; Wilson, L. InTaxane Anticancer Agents; Georg, G. I., Chen, T. T., Ojima, I., Vyas, D. M., Eds.; ACS Symposium Series 583; American Chemical Society:  Washington, DC, 1995; pp 138−153.

2. How does taxol stabilize microtubules?

3. Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution

4. Epothilons A and B: Antifungal and Cytotoxic Compounds from Sorangium cellulosum (Myxobacteria). Production, Physico-chemical and Biological Properties.

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