Design and Biological Evaluation of Novel Tubulin Inhibitors as Antimitotic Agents Using a Pharmacophore Binding Model with Tubulin-Reference-Cited by-同舟云学术

Design and Biological Evaluation of Novel Tubulin Inhibitors as Antimitotic Agents Using a Pharmacophore Binding Model with Tubulin

Published:2006-08-19 Issue:19 Volume:49 Page:5664-5670
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kim Do Yoon¹,Kim Kyun-Hwan¹,Kim Nam Doo¹,Lee Ki Young¹,Han Cheol Kyu¹,Yoon Jeong Hyeok¹,Moon Seung Kee¹,Lee Sung Sook¹,Seong Baik L.¹

Affiliation:

1. Department of Biotechnology, College of Engineering, Yonsei University, Seoul 120-749, Korea, Department of Pharmacology, School of Medicine, Konkuk University, Chungju 380-701, Korea, Institute of Life Science and Biotechnology, Yonsei University, 134 Shinchon-Dong, Seodaemun-Gu, Seoul 120-749, Korea, Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, R&D Center, Equispharm Company, Limited, 3F Sung-ok...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050761i

Reference23 articles.

1. Structural Basis for the Interaction of Tubulin with Proteins and Drugs that Affect Microtubule Dynamics

2. Microtubule dynamics and tubulin interacting proteins

3. Promotion of microtubule assembly in vitro by taxol

4. Colchicine-binding protein of mammalian brain and its relation to microtubules

5. Analogs of growth hormone-releasing factor (1-29) amide containing the reduced peptide bond isostere in the N-terminal region

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