(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans-Reference-Cited by-同舟云学术

(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans

Published:2012-04-09 Issue:8 Volume:55 Page:3644-3666
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Boatman P. Douglas,Lauring Brett¹,Schrader Thomas O.,Kasem Michelle,Johnson Benjamin R.,Skinner Philip,Jung Jae-Kyu,Xu Jerry,Cherrier Martin C.,Webb Peter J.,Semple Graeme,Sage Carleton R.,Knudsen Jens,Chen Ruoping,Luo Wen-Lin¹,Caro Luzelena¹,Cote Josee¹,Lai Eseng¹,Wagner John¹,Taggart Andrew K.¹,Carballo-Jane Ester¹,Hammond Milton¹,Colletti Steven L.¹,Tata James R.¹,Connolly Daniel T.,Waters M. Gerard¹,Richman Jeremy G.

Affiliation:

1. Merck Research Laboratories, Rahway, New Jersey, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm2010964

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4. The nicotinic acid receptor GPR109A (HM74A or PUMA-G) as a new therapeutic target

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