1. Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy, Laboratory of Proteomics and Metabonomics, S. Lucia Foundation-IRCCS, Rome, Italy, Department of Biomedical Science, University “G. D’Annunzio”, Chieti, Italy, Children’s Hospital “Bambino Gesù”-IRCCS, Rome, Italy, and Department of Laboratory Medicine, Policlinico Tor Vergata Foundation, Rome, Italy