Role of the Carboxylate in Enzyme-Catalyzed Decarboxylation of Orotidine 5′-Monophosphate: Transition State Stabilization Dominates Over Ground State Destabilization-Reference-Cited by-同舟云学术

Role of the Carboxylate in Enzyme-Catalyzed Decarboxylation of Orotidine 5′-Monophosphate: Transition State Stabilization Dominates Over Ground State Destabilization

Published:2019-07-31 Issue:34 Volume:141 Page:13468-13478
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Goryanova Bogdana¹,Amyes Tina L.¹,Richard John P.¹^ORCID

Affiliation:

1. Department of Chemistry, University at Buffalo, SUNY, Buffalo, New York 14260-3000, United States

Funder

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

http://pubs.acs.org/doi/pdf/10.1021/jacs.9b04823

Reference77 articles.

1. Orotidine 5′-Monophosphate Decarboxylase: Probing the Limits of the Possible for Enzyme Catalysis

2. Catalytic Proficiency: The Unusual Case of OMP Decarboxylase

3. OMP decarboxylase—An enigma persists

4. Orotidine Monophosphate Decarboxylase – A Fascinating Workhorse Enzyme with Therapeutic Potential

5. A Proficient Enzyme

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