Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 21. Novel 4-Alkoxy and 14-Phenylpropoxy Derivatives of the μ Opioid Receptor Antagonist Cyprodime-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 21. Novel 4-Alkoxy and 14-Phenylpropoxy Derivatives of the μ Opioid Receptor Antagonist Cyprodime

Published:2004-05-08 Issue:12 Volume:47 Page:3242-3247
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Spetea Mariana¹,Schüllner Falko¹,Moisa Radu C.¹,Berzetei-Gurske Ilona P.¹,Schraml Barbara¹,Dörfler Cynthia¹,Aceto Mario D.¹,Harris Louis S.¹,Coop Andrew¹,Schmidhammer Helmut¹

Affiliation:

1. Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria, Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, Peter-Mayr-Strasse 1, A-6020 Innsbruck, Austria, SRI International, Biosciences Division, 333 Ravenswood Avenue, Menlo Park, California 94025, Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298-0613, and...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm031126k

Reference25 articles.

1. Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective .mu. opioid receptor antagonist

2. Interaction of agonist peptide [3H]Tyr-d-Ala-Phe-Phe-NH2 with μ-opioid receptor in rat brain and CHO-μ/1 cell line

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