Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors-Reference-Cited by-同舟云学术

Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors

Published:2012-06-11 Issue:12 Volume:55 Page:5901-5921
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kulagowski Janusz J.¹²,Blair Wade¹²,Bull Richard J.¹²,Chang Christine¹²,Deshmukh Gauri¹²,Dyke Hazel J.¹²,Eigenbrot Charles¹²,Ghilardi Nico¹²,Gibbons Paul¹²,Harrison Trevor K.¹²,Hewitt Peter R.¹²,Liimatta Marya¹²,Hurley Christopher A.¹²,Johnson Adam¹²,Johnson Tony¹²,Kenny Jane R.¹²,Bir Kohli Pawan¹²,Maxey Robert J.¹²,Mendonca Rohan¹²,Mortara Kyle¹²,Murray Jeremy¹²,Narukulla Raman¹²,Shia Steven¹²,Steffek Micah¹²,Ubhayakar Savita¹²,Ultsch Mark¹²,van Abbema Anne¹²,Ward Stuart I.¹²,Waszkowycz Bohdan¹²,Zak Mark¹²

Affiliation:

1. Departments of Medicinal Chemistry and ‡Computer Aided Drug Design, Argenta, 8/9 Spire Green Centre, Harlow CM19 5TR, United Kingdom

2. Departments of Biochemical and Cellular Pharmacology, ∥Discovery Chemistry, ⊥Drug Metabolism and Pharmacokinetics, #Immunology, and ○Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300438j

Reference65 articles.

1. JAK-STAT Signaling

2. Regulation of JAK–STAT signalling in the immune system

3. Janus kinases in immune cell signaling

4. STATs: transcriptional control and biological impact

5. Signaling through the JAK/STAT pathway, recent advances and future challenges

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