Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure-Reference-Cited by-同舟云学术

Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure

Published:2009-11-20 Issue:1 Volume:53 Page:201-207
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Scapecchi Serena¹,Nesi Marta²,Matucci Rosanna²,Bellucci Cristina¹,Buccioni Michela³,Dei Silvia¹,Guandalini Luca¹,Manetti Dina¹,Martelli Cecilia¹,Martini Elisabetta¹,Marucci Gabriella³,Orlandi Francesca¹,Romanelli Maria Novella¹,Teodori Elisabetta¹,Cirilli Roberto⁴

Affiliation:

1. Dipartimento di Scienze Farmaceutiche, Università di Firenze, Via Ugo Schiff, 6, 50019 Sesto Fiorentino, Italy

2. Dipartimento di Farmacologia Preclinica e Clinica, Università di Firenze, Viale Pieraccini 6, 50139 Firenze, Italy

3. Dipartimento di Chimica, Università di Camerino, Via S.Agostino 1, 62032 Camerino (MC), Italy

4. Dipartimento del Farmaco, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901048j

Reference36 articles.

1. Muscarinic receptor subtypes in neuronal and non-neuronal cholinergic function

2. Muscarinic Receptor Subtype Pharmacology and Physiology

3. Control by cholinergic mechanisms

4. The conformational switch in muscarinic acetylcholine receptors

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