1. Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, British Columbia, Canada V6T 1Z3, Centre for Drug Research and Development, 2259 Lower Mall, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4, Centre for Blood Research and Departments of Pathology and Lab Medicine and Department of Chemistry, 2350 Health Science Mall, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3