Synthesis and Structure−Activity Relationship of N-Substituted 4-Arylsulfonylpiperidine-4-hydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis-Reference-Cited by-同舟云学术

Synthesis and Structure−Activity Relationship of N-Substituted 4-Arylsulfonylpiperidine-4-hydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis

Published:2003-05-10 Issue:12 Volume:46 Page:2376-2396
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Aranapakam Venkatesan¹,Davis Jamie M.¹,Grosu George T.¹,Baker ¹,Ellingboe John¹,Zask Arie¹,Levin Jeremy I.¹,Sandanayaka Vincent P.¹,Du Mila¹,Skotnicki Jerauld S.¹,DiJoseph John F.¹,Sung Amy¹,Sharr Michele A.¹,Killar Loran M.¹,Walter Thomas¹,Jin Guixian¹,Cowling Rebecca¹,Tillett Jeff¹,Zhao Weiguang¹,McDevitt Joseph¹,Xu Zhang Bao¹

Affiliation:

1. Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, and Wyeth Research, P.O. Box CN-8000, Princeton, New Jersey 08543

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0205550

Reference19 articles.

1. Matrix metalloproteinases

2. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

3. Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase