Parallel Synthesis of Potent, Pyrazole-Based Inhibitors of Helicobacter pylori Dihydroorotate Dehydrogenase-Reference-Cited by-同舟云学术

Parallel Synthesis of Potent, Pyrazole-Based Inhibitors of Helicobacter pylori Dihydroorotate Dehydrogenase

Published:2002-09-06 Issue:21 Volume:45 Page:4669-4678
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Haque Tasir S.¹,Tadesse Seifu¹,Marcinkeviciene Jovita¹,Rogers M. John¹,Sizemore Christine¹,Kopcho Lisa M.¹,Amsler Karen¹,Ecret Lisa D.¹,Zhan Dong Liang¹,Hobbs Frank¹,Slee Andrew¹,Trainor George L.¹,Stern Andrew M.¹,Copeland Robert A.¹,Combs Andrew P.¹

Affiliation:

1. Department of Medicinal Chemistry, Department of Chemical Enzymology, and Antimicrobials Group, Bristol-Myers Squibb Company, Experimental Station, Route 141 and Henry Clay Road, Wilmington, Delaware 19880

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm020112w

Reference23 articles.

1. Helicobacter pylori and gastric acid: Biological and therapeutic implications

2. Recombinant Human Dihydroorotate Dehydrogenase: Expression, Purification, and Characterization of a Catalytically Functional Truncated Enzyme

3. Active Site of Dihydroorotate Dehydrogenase A from Lactococcus lactis Investigated by Chemical Modification and Mutagenesis

4. The crystal structure of the flavin containing enzyme dihydroorotate dehydrogenase A from Lactococcus lactis

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