1. Department of Biochemistry, Queen's University, Kingston, Ontario K7L 3N6, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Cardiovascular, Circulatory and Respiratory Research Group, Queen's University, Kingston, Ontario K7L 3N6, Canada, and Protein Function Discovery Group, Queen's University, Kingston, Ontario K7L 3N6, Canada