Transition State Analogue Structures of Human Phosphoglycerate Kinase Establish the Importance of Charge Balance in Catalysis

Author:

Cliff Matthew J.1,Bowler Matthew W.1,Varga Andrea1,Marston James P.1,Szabó Judit1,Hounslow Andrea M.1,Baxter Nicola J.1,Blackburn G. Michael1,Vas Mária1,Waltho Jonathan P.1

Affiliation:

1. The Krebs Institute & The Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, U.K., Structural Biology Group, European Synchrotron Radiation Facility, 6 rue Jules Horowitz, F-38043 Grenoble, France, Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, P.O. Box 7, H-1518 Budapest, Hungary, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester M1 7DN, U.K.

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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