Resistance-Modifying Agents. 9. Synthesis and Biological Properties of Benzimidazole Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase
Author:
Affiliation:
1. Department of Chemistry, Bedson Building, The University, Newcastle upon Tyne NE1 7RU, U.K.; Cancer Research Unit, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.; and Agouron Pharmaceuticals Inc., San Diego, California 92121
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm000950v
Reference42 articles.
1. Involvement of poly(ADP-ribose) polymerase in base excision repair
2. The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy
3. Poly (ADP-Ribose) synthetase. Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA-binding domain, and the automodification domain.
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