siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes-Reference-Cited by-同舟云学术

siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes

Published:2015-03-02 Issue:5 Volume:10 Page:1181-1187
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Matsuda Shigeo¹,Keiser Kristofer¹,Nair Jayaprakash K.¹,Charisse Klaus¹,Manoharan Rajar M.¹,Kretschmer Philip¹,Peng Chang G.¹,V. Kel’in Alexander¹,Kandasamy Pachamuthu¹,Willoughby Jennifer L.S.¹,Liebow Abigail¹,Querbes William¹,Yucius Kristina¹,Nguyen Tuyen¹,Milstein Stuart¹,Maier Martin A.¹,Rajeev Kallanthottathil G.¹,Manoharan Muthiah¹

Affiliation:

1. Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/cb501028c

Reference25 articles.

1. RNAi therapeutics: a potential new class of pharmaceutical drugs

2. Designing Chemically Modified Oligonucleotides for Targeted Gene Silencing

3. The RNAi revolution

4. siRNA: novel therapeutics from functional genomics

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