Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor-Reference-Cited by-同舟云学术

Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor

Published:2012-11-29 Issue:1 Volume:4 Page:85-90
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Chan Bryan K.¹²,Estrada Anthony A.¹²,Chen Huifen¹²,Atherall John¹²,Baker-Glenn Charles¹²,Beresford Alan¹²,Burdick Daniel J.¹²,Chambers Mark¹²,Dominguez Sara L.¹²,Drummond Jason¹²,Gill Andrew¹²,Kleinheinz Tracy¹²,Le Pichon Claire E.¹²,Medhurst Andrew D.¹²,Liu Xingrong¹²,Moffat John G.¹²,Nash Kevin¹²,Scearce-Levie Kimberly¹²,Sheng Zejuan¹²,Shore Daniel G.¹²,Van de Poël Hervé¹²,Zhang Shuo¹²,Zhu Haitao¹²,Sweeney Zachary K.¹²

Affiliation:

1. Departments of †Discovery Chemistry, ‡Biochemical and Cellular Pharmacology, §Drug Metabolism and Pharmacokinetics, and ∥Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. Departments of ⊥Chemistry, #Biochemical and Cellular Pharmacology, and ∇Drug Metabolism and Pharmacokinetics, BioFocus, Chesterford Research Park, Saffron Walden, Essex CB10 1XL, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml3003007

Reference36 articles.

1. Parkinson's disease

2. Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology

3. Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease

4. LRRK2 in Parkinson's disease: protein domains and functional insights

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