Fine Tuning of Electrostatics around the Internucleotidic Phosphate through Incorporation of Modified 2′,4′-Carbocyclic-LNAs and -ENAs Leads to Significant Modulation of Antisense Properties-Reference-Cited by-同舟云学术

Fine Tuning of Electrostatics around the Internucleotidic Phosphate through Incorporation of Modified 2′,4′-Carbocyclic-LNAs and -ENAs Leads to Significant Modulation of Antisense Properties

Published:2008-12-04 Issue:1 Volume:74 Page:118-134
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Zhou Chuanzheng¹,Liu Yi¹,Andaloussi Mounir¹,Badgujar Naresh¹,Plashkevych Oleksandr¹,Chattopadhyaya Jyoti¹

Affiliation:

1. Department of Bioorganic Chemistry, Box 581, Biomedical Center, Uppsala University, SE-751 23 Uppsala, Sweden

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo8016742

Reference54 articles.

1. Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide.

2. Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide.

3. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

4. Antisense technologies. Improvement through novel chemical modifications

5. Mechanisms of gene silencing by double-stranded RNA

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