Synthesis, Biological Evaluation, and Conformational Analysis of A-Ring Diastereomers of 2-Methyl-1,25-dihydroxyvitamin D3 and Their 20-Epimers: Unique Activity Profiles Depending on the Stereochemistry of the A-Ring and at C-20-Reference-Cited by-同舟云学术

Synthesis, Biological Evaluation, and Conformational Analysis of A-Ring Diastereomers of 2-Methyl-1,25-dihydroxyvitamin D3 and Their 20-Epimers: Unique Activity Profiles Depending on the Stereochemistry of the A-Ring and at C-20

Published:2000-10-03 Issue:22 Volume:43 Page:4247-4265
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Konno Katsuhiro¹,Fujishima Toshie¹,Maki Shojiro¹,Liu Zhaopeng¹,Miura Daishiro¹,Chokki Manabu¹,Ishizuka Seiichi¹,Yamaguchi Kentaro¹,Kan Yukiko¹,Kurihara Masaaki¹,Miyata Naoki¹,Smith Connie¹,DeLuca Hector F.¹,Takayama Hiroaki¹

Affiliation:

1. Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199-0195, Japan, Teijin Institute for Bio-Medical Research, Teijin Ltd., Hino, Tokyo 191-8512, Japan, Chemical Analytical Center, Chiba University, Inage-ku, Chiba 263-8522, Japan, Suntory Institute for Bioorganic Research, Shimamoto, Osaka 618-8503, Japan, National Institute of Health Sciences, Setagaya, Tokyo 158-8501, Japan, and Department of Biochemistry, College of Agricultural and Life Sciences, 420 Henry Mall, University of...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm000261j

Reference84 articles.

1. 1α,25-Dihydroxyvitamin D3 induces differentiation of human myeloid leukemia cells

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