1. Chiralix B.V., P.O. Box 31070, 6503 CB Nijmegen, The Netherlands, Radboud University Nijmegen, IMM, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands, and DSM Pharma Chemicals, Advanced Synthesis, Catalysis & Development, P.O. Box 18, 6160 MD Geleen, The Netherlands