Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis

Author:

Mann Paul A.1,McLellan Catherine A.23,Koseoglu Sandra1,Si Qian1,Kuzmin Elena4,Flattery Amy1,Harris Guy1,Sher Xinwei1,Murgolo Nicholas1,Wang Hao1,Devito Kristine1,de Pedro Nuria5,Genilloud Olga5,Kahn Jennifer Nielsen1,Jiang Bo1,Costanzo Michael4,Boone Charlie4,Garlisi Charles G.1,Lindquist Susan23,Roemer Terry1

Affiliation:

1. Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

2. Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, United States

3. Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

4. Banting and Best Department of Medical Research, Terrance Donnally Centre of Cellular and Biomedical Research, University of Toronto, Toronto, Ontario, Canada

5. Fundación Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucı́a, Medina, Parque Tecnológico de Ciencias de la Salud , Avenida Conocimiento 34, 18016 Grenada, Spain

Funder

Genome Canada

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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