1. Chemical Development, GlaxoSmithKline Pharmaceuticals, Old Powder Mills, Leigh, nr. Tonbridge, Kent TN11 9AN, United Kingdom, Chemical Development, GlaxoSmithKline Pharmaceuticals, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom, and Chemical Development, GlaxoSmithKline Pharmaceuticals, Via Fleming 4, 37135 Verona, Italy