1. Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, and Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Germany, Chair of Experimental Genetics, Center of Life and Food Sciences Weihenstephan, Technical University Munich, Weihenstephan, Germany, and Department of Pharmaceutical Technology and Biopharmacy, Philipps-University, Department of Pharmaceutics and Biopharmacy, Marburg, Germany