Design and Synthesis of Peptidomimetic Protein Farnesyltransferase Inhibitors as Anti-Trypanosoma brucei Agents-Reference-Cited by-同舟云学术

Design and Synthesis of Peptidomimetic Protein Farnesyltransferase Inhibitors as Anti-Trypanosoma brucei Agents

Published:2003-12-12 Issue:2 Volume:47 Page:432-445
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ohkanda Junko¹,Buckner Frederick S.¹,Lockman Jeffrey W.¹,Yokoyama Kohei¹,Carrico Dora¹,Eastman Richard¹,de Luca-Fradley Kate¹,Davies Wendy¹,Croft Simon L.¹,Van Voorhis Wesley C.¹,Gelb Michael H.¹,Sebti Saïd M.¹,Hamilton Andrew D.¹

Affiliation:

1. Department of Chemistry, Yale University, PO Box 208107, New Haven, Connecticut 06520, Department of Medicine, University of Washington, Campus Box 357185, Seattle, Washington 98195, Departments of Chemistry and Biochemistry, Campus Box 351700, University of Washington, Seattle, Washington 98195, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, U.K., and Drug Discovery Program, H. Lee Moffitt Cancer Center & Research Institute...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030236o

Reference25 articles.

1. Farnesyltransferase Inhibitors in Cancer Therapy

2. Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues

3. Design and Synthesis of Non-Peptide Ras CAAX Mimetics as Potent Farnesyltransferase Inhibitors

4. Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors

5. Design and Synthesis of Potent Nonpeptidic Farnesyltransferase Inhibitors Based on a Terphenyl Scaffold

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