Synthesis and Structure−Activity Relationships of New 1,3-Disubstituted Cyclohexanes as Structurally Rigid Leukotriene B4 Receptor Antagonists-Reference-Cited by-同舟云学术

Synthesis and Structure−Activity Relationships of New 1,3-Disubstituted Cyclohexanes as Structurally Rigid Leukotriene B4 Receptor Antagonists

Published:1999-12-01 Issue:26 Volume:42 Page:5289-5310
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Poudrel Jean-Marc¹,Hullot Pierre¹,Vidal Jean-Pierre¹,Girard Jean-Pierre¹,Rossi Jean-Claude¹,Muller Agnès¹,Bonne Claude¹,Bezuglov Vladimir¹,Serkov Igor¹,Renard Pierre¹,Pfeiffer Bruno¹

Affiliation:

1. Laboratoire de Chimie Biomoléculaire et des Interactions Biologiques and Laboratoire de Physiologie cellulaire, CNRS 5074, Faculté de Pharmacie, 34060 Montpellier, France, Shemyakin Orchinikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow, Russia, and Société Servier-Adir, 1 rue Carle-Hébert, 92415 Courbevoie Cedex, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9910573

Reference89 articles.

1. Leukotrienes and inflammation

2. Leukotriene B4 is a potent and stereospecific stimulator of neutrophil chemotaxis and adherence

3. Leukotriene-induced neutrophil aggregation in vitro

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