Structure-Based Design of a Benzodiazepine Scaffold Yields a Potent Allosteric Inhibitor of Hepatitis C NS5B RNA Polymerase-Reference-Cited by-同舟云学术

Structure-Based Design of a Benzodiazepine Scaffold Yields a Potent Allosteric Inhibitor of Hepatitis C NS5B RNA Polymerase

Published:2009-06-09 Issue:14 Volume:52 Page:4099-4102
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Vandyck Koen¹,Cummings Maxwell D.¹,Nyanguile Origène¹,Boutton Carlo W.¹,Vendeville Sandrine¹,McGowan David¹,Devogelaere Benoit¹,Amssoms Katie¹,Last Stefaan¹,Rombauts Klara¹,Tahri Abdellah¹,Lory Pedro¹,Hu Lili¹,Beauchamp Derek A.²,Simmen Kenny¹,Raboisson Pierre¹

Affiliation:

1. Tibotec BVBA, Generaal de Wittelaan L 11B 3, B-2800 Mechelen, Belgium

2. Johnson & Johnson Pharmaceutical Research & Development, Raritan, New Jersey 08869

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9005548

Reference20 articles.

1. World Health Organization (WHO). Hepatitis C. Fact Sheet No. 164. Revised October 2000.http://www.who.int/mediacentre/factsheets/fs164/en/ (2000) .

2. The way forward in HCV treatment — finding the right path

3. The design of drugs for HIV and HCV

4. 1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside Inhibitors

5. 1,5-Benzodiazepine inhibitors of HCV NS5B polymerase

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