N-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity: Discovery of (2E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824)-Reference-Cited by-同舟云学术

N-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity: Discovery of (2E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824)

Published:2003-09-13 Issue:21 Volume:46 Page:4609-4624
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Remiszewski Stacy W.¹,Sambucetti Lidia C.¹,Bair Kenneth W.¹,Bontempo John¹,Cesarz David¹,Chandramouli Nagarajan¹,Chen Ru¹,Cheung Min¹,Cornell-Kennon Susan¹,Dean Karl¹,Diamantidis George¹,France Dennis¹,Green Michael A.¹,Howell Kobporn Lulu¹,Kashi Rina¹,Kwon Paul¹,Lassota Peter¹,Martin Mary S.¹,Mou Yin¹,Perez Lawrence B.¹,Sharma Sushil¹,Smith Troy¹,Sorensen Eric¹,Taplin Francis¹,Trogani Nancy¹,Versace Richard¹,Walker Heather¹,Weltchek-Engler Susan¹,Wood Alexander¹,Wu Arthur¹,Atadja Peter¹

Affiliation:

1. Oncology Research, Novartis Institute for Biomedical Research, 1 Health Plaza, East Hanover, New Jersey 07936-1080

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030235w

Reference35 articles.

1. Histone acetylation: a switch between repressive and permissive chromatin

2. Deacetylase Enzymes

3. Functional significance of histone deacetylase diversity

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