Mechanistic Studies of the tRNA-Modifying Enzyme QueA:  A Chemical Imperative for the Use of AdoMet as a “Ribosyl” Donor

Author:

Kinzie Sylvia Daoud1,Thern Bernd1,Iwata-Reuyl Dirk1

Affiliation:

1. Department of Chemistry, Portland State University, Portland, Oregon 97201

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference41 articles.

1. Bjork, G. R. IntRNA:  Structure, Biosynthesis, and Function; Soll, D., RajBhandary, U. L., Eds.; ASM Press:  Washington, DC, 1995; pp 165−206.

2. A new function of S-adenosylmethionine: The ribosyl moiety of AdoMet is the precursor of the cyclopentenediol moiety of the tRNA wobble base queuine

3. a) Kersten, H.; Kersten, W. InChromatography and Modification of NucleosidesPart B; Gehrke, Ch. W., Kuo, K. C. T., Eds.; Elsevier:  Amsterdam, 1990; pp B69−B108. (b) Okada, N.; Shindo-Okada, N.; Sato, S.; Itoh, Y. H.; Oda, K.; Nishimura, S.Proc. Natl. Acad. Sci. U.S.A.1978,75, 4247−4251. (c) Owenby, R. K.; Stulberg, M. B.; Jacobson, K. B.Mech. AgingDev.1979,11, 91−103. (d) White, B. N.; Tener, G. M.; Holden, J.; Suzuki, D. T.J. Mol.Biol.1973,74, 635−651.

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