Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies-Reference-Cited by-同舟云学术

Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies

Published:2008-02-29 Issue:6 Volume:51 Page:1831-1841
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sato Hiroyuki¹,Macchiarulo Antonio¹,Thomas Charles¹,Gioiello Antimo¹,Une Mizuho¹,Hofmann Alan F.¹,Saladin Régis¹,Schoonjans Kristina¹,Pellicciari Roberto¹,Auwerx Johan¹

Affiliation:

1. Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, 67404 Illkirch, France, Hôpitaux Universitaires de Strasbourg, Laboratoire de Biochimie Générale et Spécialisée, 67000 Strasbourg, France, Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, 06123 Perugia, Italy, Laboratory of Organic and Biomolecular Chemistry, Faculty of Pharmaceutical Sciences, Hiroshima International University, Kure, Hiroshima 737-0112, Japan, Department of Medicine,...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm7015864

Reference43 articles.

1. Importance of bile in regulation of intraluminal proteolytic enzyme activities in the rat

2. Enhancement of Dietary Protein Digestion by Conjugated Bile Acids

3. Endocrine functions of bile acids

4. Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

5. Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

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