The Chemical Development of CI-972 and CI-1000: A Continuous Nitration, A MgCl2/Et3N-Mediated C-Alkylation of a Chloronitropyrimidine, A Catalytic Protodediazotization of a Diazonium Salt, and an Air Oxidation of an Amine-Reference-Cited by-同舟云学术

The Chemical Development of CI-972 and CI-1000: A Continuous Nitration, A MgCl2/Et3N-Mediated C-Alkylation of a Chloronitropyrimidine, A Catalytic Protodediazotization of a Diazonium Salt, and an Air Oxidation of an Amine

Published:2001-04-20 Issue:3 Volume:5 Page:216-225
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

De Jong Randall L.¹,Davidson James G.¹,Dozeman Gary J.¹,Fiore Philip J.¹,Giri Punam¹,Kelly Margaret E.¹,Puls Timothy P.¹,Seamans Ronald E.¹

Affiliation:

1. Pfizer Global Research and Development, Holland Laboratories, 188 Howard Avenue, Holland, Michigan 49424, U.S.A.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op000298d

Reference25 articles.

1. Inhibitors of human purine nucleoside phosphorylase. Synthesis of pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase inhibitors as potentially T-cell selective immunosuppressive agents. Description of 2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one (CI-972)

2. Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(Arylmethyl) derivatives of 9-deazaguanine

3. Structure-Based Design of Inhibitors of Purine Nucleoside Phosphorylase. 4. A Study of Phosphate Mimics

4. Phosphonate derivatives of N9-benzylguanine: a new class of potent purine nucleoside phosphorylase inhibitors

5. One-Third-the-Sites Transition-State Inhibitors for Purine Nucleoside Phosphorylase

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