1. College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan, Republic of China, National Institute of Cancer Research, National Health Research Institutes, Tainan 704, Taiwan, Republic of China, Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli 350, Taiwan, Republic of China, and Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan 704, Taiwan, Republic of China