1. The ethylene ketal protecting group in organic synthesis. An undergraduate laboratory experiment
2. Preparation of 1,1-Diphenyl-1-hydroxy-3-butanone
3. The Ethylene Ketal Protecting Group Revisited: The Synthesis of 4-Hydroxy-4,4-diphenyl-2-butanone
4. Harwood, L. M.; Moody, C. J.Experimental Organic Chemistry: Principles and Practice,1st dd.Blackwell Scientific Publications:Boston, 1989; pp540−542.
5. We have followed several Grignard experiments for workup of the Grignard product. We have tried using water (Paulson et. al., Harwood and Moody); aqueous HCl solution (Weiss, H. M.J. Chem. Educ.1999,76, 76−77); and aqueous H2SO4solutions (Organic Syntheses;Wiley & Sons:New York, 1941; Collect. Vol.I, pp188−190.Furniss, B. S.; Hannaford, A. J.; Smith, P. W. G.; Tatchell, A. R.Vogel’s Practical Organic Chemistry,5th ed.Longman Scientific & Technical:New York, 1989; pp534−541). We have found that use of H2SO4solutions work best to dissolve the Mg salts that form upon the quench and make extraction much more efficient.