Imidazoquinoxaline Src-Family Kinase p56Lck Inhibitors: SAR, QSAR, and the Discovery of (S)-N-(2-Chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a Potent and Orally Active Inhibitor with Excellent in Vivo Antiinflammatory Activity-Reference-Cited by-同舟云学术

Imidazoquinoxaline Src-Family Kinase p56Lck Inhibitors: SAR, QSAR, and the Discovery of (S)-N-(2-Chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a Potent and Orally Active Inhibitor with Excellent in Vivo Antiinflammatory Activity

Published:2004-07-27 Issue:18 Volume:47 Page:4517-4529
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chen Ping¹,Doweyko Arthur M.¹,Norris Derek¹,Gu Henry H.¹,Spergel Steven H.¹,Das Jagabundhu¹,Moquin Robert V.¹,Lin James¹,Wityak John¹,Iwanowicz Edwin J.¹,McIntyre Kim W.¹,Shuster David J.¹,Behnia Kamelia¹,Chong Saeho¹,de Fex Henry¹,Pang Suhong¹,Pitt Sydney¹,Shen Ding Ren¹,Thrall Sara¹,Stanley Paul¹,Kocy Octavian R.¹,Witmer Mark R.¹,Kanner Steven B.¹,Schieven Gary L.¹,Barrish Joel C.¹

Affiliation:

1. Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030217e

Reference70 articles.

1. The role of tyrosine kinases and phosphotyrosine-containing recognition motifs in regulation of the T cell-antigen receptor-mediated signal transduction pathway

2. LEUKOCYTE PROTEIN TYROSINE KINASES:Potential Targets for Drug Discovery

3. Active and Inactive Protein Kinases: Structural Basis for Regulation

4. Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins.

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