Using PAT To Understand, Control, and Rapidly Scale Up the Production of a Hydrogenation Reaction and Isolation of Pharmaceutical Intermediate-Reference-Cited by-同舟云学术

Using PAT To Understand, Control, and Rapidly Scale Up the Production of a Hydrogenation Reaction and Isolation of Pharmaceutical Intermediate

Published:2014-11-06 Issue:1 Volume:19 Page:236-243
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Hamilton Peter¹,Sanganee Mahesh Jayantilal²,Graham Jonathan P.²,Hartwig Thoralf³,Ironmonger Alan²,Priestley Catherine²,Senior Lesley A.¹,Thompson Duncan R.¹,Webb Michael R.²

Affiliation:

1. Process Analytical Technology Group, Analytical Sciences, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.

2. Global API Chemistry, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.

3. Particle Sciences, Devices and Engineering, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op500285x

Reference15 articles.

1. Near-infrared spectroscopy applications in pharmaceutical analysis

2. Process analytical technologies and real time process control a review of some spectroscopic issues and challenges

3. Application of the near-infrared spectroscopy in the pharmaceutical technology

4. Chemometrics-Based Process Analytical Technology (PAT) Tools: Applications and Adaptation in Pharmaceutical and Biopharmaceutical Industries

5. Critical review of near-infrared spectroscopic methods validations in pharmaceutical applications

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