Toward Highly Potent Cancer Agents by Modulating the C-2 Group of the Arylthioindole Class of Tubulin Polymerization Inhibitors

Author:

La Regina Giuseppe1,Bai Ruoli2,Rensen Whilelmina Maria3,Di Cesare Erica3,Coluccia Antonio1,Piscitelli Francesco1,Famiglini Valeria1,Reggio Alessia1,Nalli Marianna1,Pelliccia Sveva4,Da Pozzo Eleonora5,Costa Barbara5,Granata Ilaria6,Porta Amalia6,Maresca Bruno6,Soriani Alessandra7,Iannitto Maria Luisa7,Santoni Angela37,Li Junjie8,Miranda Cona Marlein8,Chen Feng8,Ni Yicheng8,Brancale Andrea9,Dondio Giulio10,Vultaggio Stefania11,Varasi Mario11,Mercurio Ciro12,Martini Claudia5,Hamel Ernest2,Lavia Patrizia3,Novellino Ettore4,Silvestri Romano1

Affiliation:

1. Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur—Fondazione Cenci Bolognetti, Sapienza Università di Roma, Piazzale Aldo Moro 5, I-00185 Roma, Italy

2. Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, United States

3. Institute of Molecular Biology and Pathology (IBPM), CNR National Research Council of Italy, c/o Sapienza Università di Roma, Via degli Apuli 4, I-00185 Roma, Italy

4. Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli Federico II, Via Domenico Montesano 49, I-80131, Napoli, Italy

5. Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Via Bonanno Pisano 6, I-56126 Pisa, Italy

6. Dipartimento di Scienze Farmaceutiche, Sezione Biomedica, Università di Salerno, Via Ponte don Melillo, I-84084 Fisciano, Salerno, Italy

7. Dipartimento di Medicina Sperimentale e Patologia, Sapienza Università di Roma, Viale Regina Elena 324, I-00161 Roma, Italy

8. Theragnostic Laboratory, Department of Imaging and Pathology, Faculty of Medicine, Biomedical Sciences Group, KU Leuven, Herestraat 49, B-3000 Leuven, Belgium

9. Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3NB, U.K.

10. NiKem Research Srl, Via Zambeletti 25, I-20021 Baranzate, Milano, Italy

11. European Institute of Oncology, Via Adamello 16, I-20139 Milano, Italy

12. Genextra Group, DAC SRL, Via Adamello 16, I-20139 Milano, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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