Total Synthesis and Comparative Analysis of Orlistat, Valilactone, and a Transposed Orlistat Derivative: Inhibitors of Fatty Acid Synthase
Author:
Affiliation:
1. Department of Chemistry, Texas A&M University, College Station, Texas 77842-3012, and Cell Adhesion and Extra Cellular Matrix Biology, Burnham Institute for Medical Research, Infectious and Inflammatory Disease Center, La Jolla, California 92037
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ol061651o
Reference33 articles.
1. Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin
2. Mode of action of tetrahydrolipstatin: a derivative of the naturally occurring lipase inhibitor lipstatin
3. Orlistat Is a Novel Inhibitor of Fatty Acid Synthase with Antitumor Activity
4. A Fatty Acid Synthase Blockade Induces Tumor Cell-cycle Arrest by Down-regulating Skp2
5. Studies of the tandem Mukaiyama aldol-lactonization (TMAL) reaction: A concise and highly diastereoselective route to β-lactones applied to the total synthesis of the potent pancreatic lipase inhibitor, (−)-Panclicin D
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