1. Chemical Development, Synthetic Chemistry, GlaxoSmithKline Medicine Research Centre, Via Fleming 4, 37135, Verona, Italy, Statistical Science, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, U.K., and Chemical Development, Synthetic Chemistry, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, U.K.