Structure-Based Design of Novel Class II c-Met Inhibitors: 2. SAR and Kinase Selectivity Profiles of the Pyrazolone Series-Reference-Cited by-同舟云学术

Structure-Based Design of Novel Class II c-Met Inhibitors: 2. SAR and Kinase Selectivity Profiles of the Pyrazolone Series

Published:2012-02-24 Issue:5 Volume:55 Page:1868-1897
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Longbin¹²,Norman Mark H.¹²,Lee Matthew¹²,Xi Ning¹²,Siegmund Aaron¹²,Boezio Alessandro A.¹²,Booker Shon¹²,Choquette Debbie¹²,D’Angelo Noel D.¹²,Germain Julie¹²,Yang Kevin¹²,Yang Yajing¹²,Zhang Yihong¹²,Bellon Steven F.¹²,Whittington Douglas A.¹²,Harmange Jean-Christophe¹²,Dominguez Celia¹²,Kim Tae-Seong¹²,Dussault Isabelle¹²

Affiliation:

1. Departments of Medicinal Chemistry, ‡Oncology Research, and §Molecular Structure, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States

2. Departments of Medicinal Chemistry and ⊥Molecular Structure, Amgen Inc., 360 Binney Street, Cambridge, Massachusetts 02142, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201331s

Reference61 articles.

1. Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

2. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor.

3. Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF

4. Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair

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