Statistical Modeling of the Drug Load Distribution on Trastuzumab Emtansine (Kadcyla), a Lysine-Linked Antibody Drug Conjugate-Reference-Cited by-同舟云学术

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Statistical Modeling of the Drug Load Distribution on Trastuzumab Emtansine (Kadcyla), a Lysine-Linked Antibody Drug Conjugate

Published:2014-06-24 Issue:7 Volume:25 Page:1223-1232
ISSN:1043-1802
Container-title:Bioconjugate Chemistry
language:en
Short-container-title:Bioconjugate Chem.

Author:

Kim Michael T.¹,Chen Yan¹,Marhoul Joseph¹,Jacobson Fred¹

Affiliation:

1. Departments of Protein Analytical Chemistry and ‡Biostatistics Genentech, Inc, South San Francisco, California 94080 United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Pharmaceutical Science,Pharmacology,Biomedical Engineering,Bioengineering,Biotechnology

Link

https://pubs.acs.org/doi/pdf/10.1021/bc5000109

Reference23 articles.

1. Targeted Cancer Therapy: Conferring Specificity to Cytotoxic Drugs

2. Arming antibodies: prospects and challenges for immunoconjugates

3. Therapeutic potential of CD22-specific antibody-targeted chemotherapy using inotuzumab ozogamicin (CMC-544) for the treatment of acute lymphoblastic leukemia

4. Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody–Cytotoxic Drug Conjugate

5. Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas

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