Discovery of (2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic Acid Hydrochloride (GAP-134)13, an Orally Active Small Molecule Gap-Junction Modifier for the Treatment of Atrial Fibrillation

Author:

Butera John A.1,Larsen Bjarne Due1,Hennan James K.1,Kerns Edward1,Di Li1,Alimardanov Asaf1,Swillo Robert E.1,Morgan Gwen A.1,Liu Kun1,Wang Qiang1,Rossman Eric I.1,Unwalla Rayomand1,McDonald Leonard1,Huselton Christine1,Petersen Jørgen S.1

Affiliation:

1. Chemical Sciences, Wyeth Research, CN 8000, Princeton, New Jersey 08543, Chemical Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, Chemical Sciences, Drug Safety and Metabolism, and Cardiovascular and Metabolic Diseases, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, and Zealand Pharma A/S, Smedeland 36 DK-2600 Glostrup, Denmark

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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