Discovery of (2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic Acid Hydrochloride (GAP-134)13, an Orally Active Small Molecule Gap-Junction Modifier for the Treatment of Atrial Fibrillation-Reference-Cited by-同舟云学术

Discovery of (2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic Acid Hydrochloride (GAP-134)13, an Orally Active Small Molecule Gap-Junction Modifier for the Treatment of Atrial Fibrillation

Published:2009-01-28 Issue:4 Volume:52 Page:908-911
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Butera John A.¹,Larsen Bjarne Due¹,Hennan James K.¹,Kerns Edward¹,Di Li¹,Alimardanov Asaf¹,Swillo Robert E.¹,Morgan Gwen A.¹,Liu Kun¹,Wang Qiang¹,Rossman Eric I.¹,Unwalla Rayomand¹,McDonald Leonard¹,Huselton Christine¹,Petersen Jørgen S.¹

Affiliation:

1. Chemical Sciences, Wyeth Research, CN 8000, Princeton, New Jersey 08543, Chemical Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, Chemical Sciences, Drug Safety and Metabolism, and Cardiovascular and Metabolic Diseases, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, and Zealand Pharma A/S, Smedeland 36 DK-2600 Glostrup, Denmark

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801558d

Reference23 articles.

1. Studies on heart. XIX. Isolation of an atrial peptide that improves the rhythmicity of cultured myocardial cell clusters.

2. Studies on heart. XX. Further effects of bovine ventricle protein (BVP) and antiarrhythmic peptide (AAP) on myocardial cells in culture.

3. A new antiarrhythmic peptide, N-3-(4-hydroxyphenyl)propionyl Pro-Hyp-Gly-Ala-Gly.

4. Antiarrhythmic peptide has no direct cardiac actions

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