Design and Crystal Structures of Protein Kinase B-Selective Inhibitors in Complex with Protein Kinase A and Mutants-Reference-Cited by-同舟云学术

Design and Crystal Structures of Protein Kinase B-Selective Inhibitors in Complex with Protein Kinase A and Mutants

Published:2004-12-16 Issue:1 Volume:48 Page:163-170
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Breitenlechner Christine B.¹,Friebe Walter-Gunar¹,Brunet Emmanuel¹,Werner Guido¹,Graul Klaus¹,Thomas Ulrike¹,Künkele Klaus-Peter¹,Schäfer Wolfgang¹,Gassel Michael¹,Bossemeyer Dirk¹,Huber Robert¹,Engh Richard A.¹,Masjost Birgit¹

Affiliation:

1. Abteilung Strukturforschung, Max-Planck-Institut fuer Biochemie, 82152 Martinsried, Germany, Department of Medicinal Chemistry, Roche Diagnostics GmbH, 82372 Penzberg, Germany, and Department for Pathochemistry, German Cancer Research Center, 69120 Heidelberg, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm049701n

Reference42 articles.

1. Protein kinases — the major drug targets of the twenty-first century?

2. The PI3K–PDK1 connection: more than just a road to PKB

3. Mechanism of activation and function of protein kinase B

4. Oncogenic kinase signalling

5. Cellular survival: a play in three Akts

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