Efficient Enantioselective Synthesis of Sertraline, a Potent Antidepressant, via a Novel Intramolecular Nucleophilic Addition to Imine
Author:
Affiliation:
1. Process Research Department, Merck Research Laboratories, Rahway, New Jersey 07065
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ol990608g
Reference9 articles.
1. Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins
2. A catalytic enantioselective synthetic route to the important antidepressant sertraline
3. Additions of Organometallic Reagents to CN Bonds: Reactivity and Selectivity
4. Asymmetric conjugate addition
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