Pilot-Scale Continuous Production of LY2886721: Amide Formation and Reactive Crystallization
Author:
Affiliation:
1. Small Molecule Design and Development, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op500204z
Reference25 articles.
1. Continuous Processing in the Pharmaceutical Industry
2. May, S. A.; Johnson, M. D.Continuous Processing to Enable More Efficient Synthetic Routes and Improved Process Safety.Pharmaceutical Outsourcing[Online] 2013, Vol.14,issue 5;http://www.pharmoutsourcing.com/Featured-Articles/146709-Continuous-Processing-to-Enable-More-Efficient-Synthetic-Routes-and-Improved-Process-Safety/(accessed June 3, 2014) .
3. Development of a Continuous Schotten–Baumann Route to an Acyl Sulfonamide
4. Development and Scale-Up of a Continuous, High-Pressure, Asymmetric Hydrogenation Reaction, Workup, and Isolation
5. End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation
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