Design of Novel Neurokinin 1 Receptor Antagonists Based on Conformationally Constrained Aromatic Amino Acids and Discovery of a Potent Chimeric Opioid Agonist-Neurokinin 1 Receptor Antagonist-Reference-Cited by-同舟云学术

Design of Novel Neurokinin 1 Receptor Antagonists Based on Conformationally Constrained Aromatic Amino Acids and Discovery of a Potent Chimeric Opioid Agonist-Neurokinin 1 Receptor Antagonist

Published:2011-03-17 Issue:7 Volume:54 Page:2467-2476
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ballet Steven¹,Feytens Debby¹,Buysse Koen¹,Chung Nga N.²,Lemieux Carole²,Tumati Suneeta³,Keresztes Attila³,Van Duppen Joost⁴,Lai Josephine³,Varga Eva³,Porreca Frank³,Schiller Peter W.²,Vanden Broeck Jozef⁴,Tourwé Dirk¹

Affiliation:

1. Department of Organic Chemistry, Vrije Universiteit Brussel, B-1050 Brussels, Belgium

2. Department of Chemical Biology and Peptide Research, Clinical Research Institute, Montreal, Québec H2W 1R7, Canada

3. Department of Pharmacology, University of Arizona, Tucson, Arizona 85724, United States

4. Animal Physiology and Neurobiology, Zoological Institute, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm1016285

Reference59 articles.

1. Neurokinin-receptor antagonists: pharmacological tools and therapeutic drugs

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5. Neurokinin receptor antagonists

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