1. ProteoSys AG, Carl-Zeiss.-Str. 51, D-55129 Mainz, Germany, Federal Institute for Risk Assessment, Center for Alternative Methods to Animal Experiments - ZEBET Diedersdorfer Weg 1, 12277 Berlin, Germany, Johnson & Johnson PRD, a division of Janssen Pharmaceutical, 2340 Beerse, Belgium, European Centre for the Validation of Alternative Methods (ECVAM) (IHCP, JRC), Via Fermi, 121020 Ispra, Italy