1. VTT Chemical Technology, P.O. Box 1401, FIN-02044 VTT, Finland, Golder Associates, Ruosilankuja 3E, FIN-00390 Helsinki, Finland, Department of Pharmacy, Division of Pharmaceutical Chemistry, P.O. Box 56, FIN-00014 University of Helsinki, Finland, and Viikki Drug Discovery Technology Center, Department of Pharmacy, P.O. Box 56, FIN-00014 University of Helsinki, Finland