2-Oxo-3-alkynoic Acids, Universal Mechanism-Based Inactivators of Thiamin Diphosphate-Dependent Decarboxylases: Synthesis and Evidence for Potent Inactivation of the Pyruvate Dehydrogenase Multienzyme Complex-Reference-Cited by-同舟云学术

2-Oxo-3-alkynoic Acids, Universal Mechanism-Based Inactivators of Thiamin Diphosphate-Dependent Decarboxylases: Synthesis and Evidence for Potent Inactivation of the Pyruvate Dehydrogenase Multienzyme Complex

Published:1997-07-01 Issue:26 Volume:36 Page:8071-8081
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Brown Angela¹,Nemeria Natalia¹,Yi Jizu¹,Zhang Deqi¹,Jordan William B.¹,Machado Rosane S.¹,Guest John R.¹,Jordan Frank¹

Affiliation:

1. Department of Chemistry, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, and Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, U.K.

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi970094y

Reference57 articles.

1. (E)-4-(.alpha.-Halo-p-tolyl)-2-oxo-3-butenoic acids inhibit yeast pyruvate decarboxylase by a diversity of mechanisms: multiple fate for the thiamin-bound enamine intermediate

2. Escherichia coli pyruvate dehydrogenase complex. Thiamin pyrophosphate-dependent inactivation by 3-bromopyruvate.

3. Baburina, I. (1996) Ph.D. Dissertation, Rutgers University Graduate Faculty, Newark, NJ.

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